Artisanal mining is associated with a number of environmental impacts, including deforestation and land degradation, open pits which pose animal traps and health hazards, and heavy metals contamination of land (water and soil), dust and noise pollution. The study examines the perception of environmental degradation of gold mining sites in eastern Cameroon. Human-environment interaction and distance decay models are the conceptual framework for this study. This study employed a survey research design through the use of primary data while a purposive sampling technique was utilized. A total of 440 questionnaires were administered to selected households across the localities in the study area. Frequencies, percentages, chart, cross tabulations and chi-square tests were used for the data analysis. In other to achieve the aim of this study, a comparison between the nearby and far away residents were done. The study revealed that mining exploitations have brought about changes in the colour and taste of water in the active mining sites (41.7%). Malaria is the number one type of disease that has caused more damage in the localities (81.6%). Mining activities have successfully enabled children in the active mining sites to abandoned school for mining (75.0%). Inhabitants of unit 1 directly linked the problems facing their economic activities to inadequate arable land for agriculture (33.8%) and inhabitants across the study area correlated the problems facing livestock farming to diseases as a result of mining activities (64.6%). The perceived negative effects of gold mining on different socio-economic variables (such as culture, health, education, economy and livestock) vary significantly depending on the proximity from the mining areas (p<0.05). The study concludes that residents living within and far away from the active mining sites were affected by gold mining activities. However, the most worrisome situation concern people working and living within the active mining sites. Therefore, the study recommends that: companies that are involved in mining activities and the government should embark on development projects such as portable water, schools, hospitals, roads, markets, communications facilities in the affected communities.