This experimental study mainly focused on investigation of the performance of diesel engine using palm oil methyl ester (POME). The engine operating conditions such as optimized IT of 27°BTDC and varied IOP with nozzle geometry and combustion chamber shapes were investigated. The better operating conditions of combustion chamber shape and nozzle geometry were reported. The operating conditions of the engine were maintained 1500 rpm and CR of 17.5. For diesel engine operation with POME, it could be revealed that IT of 27°BTDC, IOP of 240 bar, 5 holes nozzle geometry with Torroidal Re-entrant combustion chamber (TRCC) gives more improvement in brake thermal efficiency (BTE) with minimum emissions.