The article provides information on transportation of health-hazardous waste. Transport accidents of hazardous waste are frequent and can cause serious injuries in inhabited areas or pollution to the environment. It is very important to distinguish such waste from the general waste stream and correctly transport and handle it. For qualitative risk assessment and mitigation planning, consequence calculations are necessary. Transportation of the hazardous waste has a major impact on road traffic and safety. Therefore, it is very important to define all elements of the safe system and apply the concept of “green logistics”. The aim of this article is to analyse the peculiarities of health hazards, its transportation characteristics and suggest an algorithm for determining the consignment volume and selecting transportation method in order to prevent damage to the environment and humans and minimize the risks. The scope of article is safe and sustainable transportation of hazardous waste. The article reports the results of the methodology to determine an optimal consignment volume and transportation methods, where the optimality criteria is the general storage and transportation costs is suggested. The algorithm enables to optimally determine an average number of vehicles in accordance with the tonnage of hazardous waste.